![]() Currently, around 140 genetic variants have been identified by genome-wide association studies (GWAS) explaining ~12% of the variability in colorectal cancer risk. The etiology of colorectal cancer involves a complex interplay between genetic and environmental determinants. ![]() These results suggest that variation in genes related to insulin signaling ( SLC30A8) and immune function ( LRCH1) may modify the association of diabetes with colorectal cancer risk and provide novel insights into the biology underlying the diabetes and colorectal cancer relationship.Ĭolorectal cancer is the third most common cancer globally with an estimated number of 1.9 million new cases in 2020. joint test) and G-diabetes correlation (3-d.f. ![]() We used data from 3 genetic consortia (CCFR, CORECT, GECCO 31,318 colorectal cancer cases/41,499 controls) and undertook genome-wide gene-environment interaction analyses with colorectal cancer risk, including interaction tests of genetics(G)xdiabetes (1-degree of freedom d.f.) and joint testing of Gxdiabetes, G-colorectal cancer association (2-d.f. To address these questions, we undertook a genome-wide gene-environment interaction analysis. However, the mechanisms underlying this relationship still require investigation and it is not known if the association is modified by genetic variants.
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